Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

The ME/CFS Collaboration
at Uppsala University

State-of-the-art laboratory searching for biomarkers of
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) in body and brain

Core Aims

What we hope to achieve


Our fundamental philosophy

Science Team

List of scientific collaborators


Current research projects

About the research centER

Established in 2019, this research center is directed by Jonas Bergquist, MD, PhD. Prior to this new center, Dr. Bergquist had already been researching ME/CFS for nearly a decade. Dr. Bergquist and his lab develop novel methods for extracting patient samples and measuring the metabolites and proteins within those samples. They then apply these methods to produce unique and valuable data from a range of diseases.  Along with ME/CFS, his lab has a general interest in neurodegenerative diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). 

The ME/CFS CRC at Uppsala University is looking for ME/CFS biomarkers to develop a diagnostic test and to contribute to the understanding of what initiates the disease process.  Not only are they looking for single metabolites or proteins, they are looking for the pattern of all the data the extract from ME/CFS patient samples and are working towards a defining biochemical signature of the disease.

This collaborative research initiative is looking to develop methods to measure proteins, peptides and metabolites in the blood and cerebrospinal fluid of ME/CFS patients to help define the underlying biological cause, to form a diagnostic and to ultimately find treatments for the disease. 

Core Aims

Fundamental Philosophy

Current Studies

Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS

From the Desk of Jonas Bergquist, MD, PhD Uppsala University On behalf of my team at the ME/CFS Collaborative Research Centre at Uppsala University, I am …

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Kynurenine Trial in ME / CFS

Kynurenine Trial in ME / CFS STUDY AIM The purpose of the study is to evaluate whether kynurenine is directly connected to ME / CFS patient symptom severity. LEAD …

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Post-viral Encephalopathy

Herpes Simplex Encephalopathy and the Development of ME / CFS STUDY AIM To investigate the correlation between biomarkers for brain injury and long-term neurocognitive outcome, and the …

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Autoimmunity and Autoantibodies

Autoimmunity and Autoantibodies in ME/CFS Study AIM Investigate potential differences in adrenergic and muscarinic receptor autoantibody levels in plasma and cerebrospinal fluid (CSF) samples between …

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Kynurenine Clinical Trial for ME / CFS

Open Medicine Foundation is excited to announce its support of an initiation of a clinical trial to understand potential disturbances in the tryptophan metabolism and …

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View our latest news

Post-COVID Syndrome to ME/CFS

In 2020, OMF secured a $1 million grant to launch the first year of an international, multi-year study across the five OMF funded Collaborative Research Centers (CRC). The aim of this study is to examine Post-COVID Syndrome transitioning to ME/CFS. We are actively working to raise an additional $2 million for years two and three of the study. I am pleased to share with you an update on the first phase of this groundbreaking — and urgently needed — research project.

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Scientific Team

The large-scale research endeavors of the ME / CFS Collaborative Research Center at Uppsala University require a diverse team. Dr. Bergquist has assembled a great team of scientists and clinicians to fulfill their goals.

Uppsala University (Sweden)

Jonas Bergquist, MD, PhD, Prof, Director

Kumari Ubhayasekhera, PhD

Sandy Abujrais. PhD Student

Annie Bynke, Med Student

Torsten Gordh, MD, PhD, Prof em


Massachusetts General Hospital (Harvard)

Ronald Tompkins, MD, ScD

Wenzhong Xiao, PhD


Stanford University

Ronald Davis, PhD


Karolinska Institut (Sweden)

Per Julin, MD, PhD

Anders Rehnström, MD

Anna Lindquist, MD

Emelie Karlsson, RN

Bragee Clinics Stockholm

Bo C. Bertilsson, MD, PhD

Björn Bragée, MD

Gunnar Olsson, MD, PhD, Ass. Prof

Jonas Axelsson, MD, PhD, Ass. Prof

Britt Bragée, RPT, PhD

Gabriella Bernhoff RPT, PhD Student

Brandon Drum, Med Student

Michael Fahlqvist, MD-internship

Michos Anastasios, MD


Gottfries clinic (Sweden)

CG Gottfries, MD, PhD, Prof em

Linkoping University (Sweden)

Anders Rosén, MD, PhD, Prof em

Björn Ingelsson,  PhD, Ass prof

Eirini Apostoulo, PhD, Post doc

Rizwan Muhammad, Guest Researcher


University of East Anglia (UK)

Simon Carding, PhD, Prof


Charite Universitatsmedizin Berlin

Carmen Scheibenbogen, MD, PhD, Prof


Open Medicine Foundation

Linda Tannenbaum

Chris Armstrong, PhD

Learn about Our Other OMF Funded Collaborative Research Centers

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®


Averting a second pandemic:

Open Medicine Foundation leads groundbreaking international study of

Long COVID’s conversion to ME/CFS

AGOURA HILLS, CALIF.  — Open Medicine Foundation (OMF) is leading a large-scale international collaborative study investigating the potential conversion of Post-Acute Sequelae SARS-CoV-2 infection — more commonly known as Long COVID or Post-COVID Syndrome —  to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic, life-altering disease with no known cause, diagnostic test or FDA approved treatments available.

Up to 2.5 million people in the U.S. alone suffer from ME/CFS; the COVID-19 pandemic could at least double that number. An estimated 35 percent of Americans who had COVID-19 have failed to fully recover several months after infection, prompting many to call it “a potential second pandemic.”

OMF recognized a familiar health crisis emerging, one with eerie similarities to ME/CFS. This crisis presented a unique opportunity to understand how a viral infection — in this case COVID-19 — may develop into ME/CFS in some patients. The goal is to find targeted treatments for ME/CFS patients and ultimately prevent its onset in people infected with SARS-CoV-2 or other infections.

The federal government is only now investing in Post-COVID research, with no focus on its connection to ME/CFS. OMF has already engaged researchers for the largest-scale study of its kind, solely supported by private donors who have contributed over one million dollars to date. When fully funded, the five million dollar, three-year study will be conducted across the globe at OMF funded Collaborative Research Centers, led by some of the world’s top researchers and ME/CFS experts.


In a significant percentage of patients, infections preceded their development of ME/CFS.  For example, according to the CDC about one in ten infected with Epstein-Barr virus, Ross River virus, or Coxiella burnetti develop symptoms that meet the criteria for ME/CFS.


The ability to follow the development of ME/CFS from a known viral infection is unprecedented to date and crucial to researchers’ understanding of the disease. The focus of this study is to find the biological differences between persons returning to good health after COVID-19 and persons who remained ill more than six months after infection and developed ME/CFS.  Understanding these alterations in key pathways can lead to groundbreaking discoveries including new biomarkers, drug targets, and prevention and treatment strategies.


About Open Medicine Foundation

Established in 2012, Open Medicine Foundation leads the largest, concerted worldwide nonprofit effort to diagnose, treat, and prevent ME/CFS and related chronic, complex diseases such as Post Treatment Lyme Disease Syndrome, Fibromyalgia, and Post COVID. OMF adds urgency to the search for answers by driving transformational philanthropy into global research. We have raised over $28 Million from private donors and facilitated and funded the establishment of five prestigious ME/CFS Collaborative Research Centers around the world. To learn more, visit www.omf.ngo.


Heather Ah San

Development and Communications Manager