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ME/CFS and related chronic complex diseases

The Harvard ME/CFS Collaboration

at the Harvard Affiliated Hospitals

Clinical and scientific studies to understand ME/CFS and discover new treatments

Core Aims

What we hope to achieve

Philosophy

Our fundamental philosopy

Science Team

List of scientific collaborators

Research

Current
research projects

About the research center

Established in 2018, this research initiative is based at Harvard affiliated hospitals, including Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and Beth Israel Deaconess Medical Center (BIDMC).

Including the faculty of the Harvard affiliated hospitals, critical collaborations are represented from Stanford University, Cornell University, University of Birmingham, University of Nottingham, Uppsala University and Pacific Northwest National Laboratory.

This collaborative research center is co-led by Ronald G. Tompkins, MD, ScD and Wenzhong Xiao, PhD. This research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of ME/CFS patients.

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Ronald G. Tompkins, MD, ScD
Wenzhong Xiao, PhD

Core Aims

Understand

the underlying basis of post-exertional malaise and/or post-muscular stress

Determine

the role of neuroinflammation in ME/CFS

Diagnose

possible pathologies associated with ME/CFS patients

Ascertain

the role of circulation and autonomic issues in ME/CFS

Increase

efficiency of clinical visits for ME/CFS patients to significantly reduce wait times

Develop

the infrastructure to begin treatment trials and form a center of excellence for ME/CFS

Fundamental Philosophy

Work collaboratively with other groups
Use the most advanced technology available to perform the research
Explore the research community to find experts in the areas to study
Take direct measures from ME/CFS patients to avoid artificial observations
Research multiple tissues of the body and consider stark differences of different cell types

The Research

Co-led by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD., this research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of ME/CFS patients.

IMG_6567[1]

Current Studies

Heart Preload Failure

Heart Preload Failure Study Aim This study aims to evaluate these different explanations of PLF in ME/CFS patients to determine which is active in many, if not all, ME/CFS patients. […]

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Skeletal Muscle Dysfunction Research

Skeletal Muscle Dysfunction Research sTUDY aIM This project aims to explore the biological changes that occur in the muscles during Post-exertional Malaise (PEM). LEAD INVESTIGATORS Ronald Tompkins, PhD Wenzhong Xiao, […]

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Brain Nuclear Inflammation

Brain Nuclear Inflammation Study Aim This project aims to better understand the role of neuroinflammation in ME/CFS. LEAD INVESTIGATORS Ronald Tompkins, PhD Wenzhong Xiao, PhD David Systrom, MD Michael VanElzakker, […]

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Computerized Adaptive Testing

Computerized Adaptive Testing TECHNOLOGY Aim Given meager research funding and the absence of a consensus on disease mechanism, there has been no definition or single set of criteria that has […]

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Multi-omics of iCPET Plasma Samples

Multi-omics of iCPET Plasma Samples sTUDY aIM This project aims to understand the origin of postural orthostatic tachycardia syndrome (POTS).   LEAD INVESTIGATORS Ronald Tompkins, PhD Wenzhong Xiao, PhD David […]

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Scientific Team

To carry out these ambitious collaborations, Drs. Tompkins and Xiao together with the many Harvard Medical School faculty are establishing networks and collaborations extending to the UK and other US-based institutions. They have assembled a team of superb clinicians and scientists with expertise in a wide variety of areas directly relevant to ME/CFS research.

Harvard_MECFS_ScientificGroup-June-2019-crop-1[1]
Massachusetts General Hospital
Ronald Tompkins, MD, ScD
Wenzhong Xiao, PhD
Donna Felsenstein, MD
Jonathan Friedstat, MD
Daniel Irimia, MD, PhD
Amel Karaa, MD
Michael VanElzakker, PhD
H. Shaw Warren, MD
Yongming Yu, MD, PhD
Andrew Alexander, MBA
Brigham & Womens Hospital
David Systrom, MD
Anthony Komaroff, MD
BI Deaconess Medical Center
Janet Mullington, PhD
Pacific Northwest National Laboratory
Richard Smith, PhD
John Jacob, PhD
Wei-Jun Qian, PhD
University of Nottingham, UK
Philip Atherton, PhD
Paul Greenhaff, PhD
University of Birmingham, UK
Janet Lord, PhD
Cornell University
Maureen Hanson, PhD
Open Medicine Foundation
Linda Tannenbaum
Chris Armstrong, PhD
Stanford University
Ronald Davis, PhD
Uppsala University, Sweden
Jonas Bergquist, MD, PhD

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