STUDY HYPOTHESIS AND DESCRIPTION
Dr. Systrom has consistently found that some people with ME/CFS suffering from fatigue have Preload Failure (PLF). In this instance, PLF is thought to come from an imbalance in the autonomic nervous system and results in reduced filling of the heart during exertion.
Prior studies have shown that treatment with Mestinon results in symptomatic improvement in patients with PLF. Dr. Systrom intends to evaluate the short-term effects of Mestinon on the autonomic nervous system and neurovascular control in people with ME/CFS with PLF. Studying these features will improve our understanding of ME/CFS and this trial may lead to new therapeutic options for some people with ME/CFS.
More details of this trial can be found here.
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