Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

The Harvard ME/CFS Collaboration

at the Harvard Affiliated Hospitals

Clinical and scientific studies to understand Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) and discover new treatments

Core Aims

What we hope to achieve

Philosophy

Our fundamental philosophy

Science Team

List of scientific collaborators

Research

Current research projects

About the research center

Established in 2018, this research initiative is based at Harvard affiliated hospitals, including Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and Beth Israel Deaconess Medical Center (BIDMC). 

Including the faculty of the Harvard affiliated hospitals, critical collaborations are represented from Stanford University, Cornell University, University of Birmingham, University of Nottingham, Uppsala University and Pacific Northwest National Laboratory. 

This collaborative research center is co-led by Ronald G. Tompkins, MD, ScD and Wenzhong Xiao, PhD. This research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of ME/CFS patients. 

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Core Aims

Fundamental Philosophy

The Research

Co-led by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD., this research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) patients. 

Current Studies

Heart Preload Failure

Heart Preload Failure STUDY AIM This study aims to evaluate these different explanations of PLF in ME / CFS patients to determine which is active in many, …

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The Mestinon Clinical Trial for ME / CFS

Open Medicine Foundation is delighted to announce its support of a clinical trial to test the exercise response to Mestinon in people with Myalgic Encephalomyelitis / Chronic …

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Skeletal Muscle Dysfunction Research

Skeletal Muscle Dysfunction Research STUDY AIM This project aims to explore the biological changes that occur in the muscles during Post-exertional Malaise (PEM). LEAD INVESTIGATORS …

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Computerized Adaptive Testing

Computerized Adaptive Testing TECHNOLOGY AIM Given meager research funding and the absence of a consensus on disease mechanism, there has been no definition or single …

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Multi-omics of iCPET Plasma Samples

Multi-omics of iCPET Plasma Samples STUDY AIM This project aims to understand the origin of postural orthostatic tachycardia syndrome (POTS). LEAD INVESTIGATORS Ronald Tompkins, MD …

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Scientific Team

To carry out these ambitious collaborations, Drs. Tompkins and Xiao together with the many Harvard Medical School faculty are establishing networks and collaborations extending to the UK and other US-based institutions. They have assembled a team of superb clinicians and scientists with expertise in a wide variety of areas directly relevant to Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) research. 

Massachusetts General Hospital

Ronald Tompkins, MD, ScD

Wenzhong Xiao, PhD

Donna Felsenstein, MD

Jonathan Friedstat, MD

Daniel Irimia, MD, PhD

Amel Karaa, MD

Michael VanElzakker, PhD

H. Shaw Warren, MD

Yongming Yu, MD, PhD

Andrew Alexander, MBA

Brigham & Womens Hospital

David Systrom, MD

Anthony Komaroff, MD

 

BI Deaconess Medical Center

Janet Mullington, PhD

 

Pacific Northwest National Laboratory

Richard Smith, PhD

John Jacob, PhD

Wei-Jun Qian, PhD

University of Nottingham, UK

Philip Atherton, PhD

Paul Greenhaff, PhD

 

University of Birmingham, UK

Janet Lord, PhD

 

Cornell University

Maureen Hanson, PhD

Open Medicine Foundation

Linda Tannenbaum

Chris Armstrong, PhD

 

Stanford University

Ronald Davis, PhD

 

Uppsala University, Sweden

Jonas Bergquist, MD, PhD

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