This study explores the biological changes that occur in the muscles during post-exertional malaise (PEM), both in historical cases of ME/CFS and cases of Long COVID that meet the criteria for ME/CFS.
The aim is to investigate potential differences in adrenergic and muscarinic receptor autoantibody levels in plasma and cerebrospinal fluid samples between ME/CFS patients and healthy controls.
Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM). This includes deep phenotyping of ME patients and global proteomic/metabolomics plasma profiling of ME..
We intend to examine multiple sleep studies that have been conducted in the past two years and performed at the MGH Neurology Sleep Medicine Laboratory in well characterized patients with ME/CFS.
We will explore the hypothesis that deranged flow of the cerebrospinal fluid (CSF) due to craniocervical obstructions and/or instability may cause deranged intracranial pressure (ICP), neuroinflammation and cardinal symptoms of ME/CFS.
This study provides an excellent opportunity to understand the mechanism of long-lasting viral-induced cognitive complications, commonly referred to as “brain fog.”
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