Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long Covid

Grant Awarded to Nitrogen Hypothesis Study

 OMF Scientist Receives
Grant Funding for ME / CFS Study

Open Medicine Foundation (OMF) is thrilled to share that our staff science liaison, Christopher W. Armstrong, PhD, has been awarded a grant to further his research into the relationship between the altered metabolism of nitrogen and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME / CFS). The research will be completed at the ME / CFS Collaborative Research Center at Stanford University, under the direction of Dr. Ron Davis, Director of OMF’s Scientific Advisory Board.

Dr. Armstrong first noted increased usage of amino acids, which contains nitrogen, in the metabolism of people with ME / CFS while working at the University of Melbourne. He was the first to apply metabolomics to the field of ME / CFS, publishing his results in 2015. Metabolomics is the study of small molecules (metabolites) using common standards of detection that enable different studies to be comparative and additive.

In 2018, he defined a hypothesis thatnitrogen-containing by-products of energy production accumulate more readily in the cells of people with ME / CFS, these nitrogen-containing by-products can be damaging to the cells and their process of producing energy.” This means that the process of producing energy in people with ME / CFS may be causing damage and could reduce their ability to make further energy.

Chris was recruited to join Open Medicine Foundation in 2019 as a science liaison to communicate between the research collaborative groups at Stanford, Harvard, Uppsala, and Montreal universities, as well to help communicate their work to the broader ME / CFS community. During this time, he further developed the nitrogen hypothesis as it pertains to the broader research findings in the ME / CFS field.

“I’m extremely excited to have received funding for the continuation of this research. This hypothesis is the culmination of the many research studies on people with ME / CFS,” Dr. Armstrong says. “We will be able to test the hypothesis, and in the process, we will be providing a large body of data on nitrogen metabolism in ME / CFS.”

The grant will fund over 10,000 measurements of molecules in biofluids and cells from people, with and without ME / CFS, to track how nitrogen flows through the energy production system.


We Won a GreatNonprofit Award!

Thanks to our wonderful community, Open Medicine Foundation is one of the first winners of the 2020 Top-Rated Award from GreatNonprofits! GreatNonprofits, the leading platform for community-sourced stories about nonprofits, honors highly reviewed nonprofit organizations with their 2020 Top-Rated Awards.

OMF’s 2020 GreatNonprofits badge proudly demonstrates our commitment to transparency as a nonprofit organization, and serves to increase visibility of our work and expand our network of generous donors dedicated to ending ME / CFS.

We are truly grateful to have received such a positive response from our community:

“OMF is continuously researching ME / CFS and giving patients hope!”

“COLLABORATION. A powerful way to achieve results, when researching a disease so complex such as ME / CFS — and collaboration is in the core of the work at OMF. This nonprofit organization has already achieved groundbreaking discoveries and will continue to do so, aiming to find treatment for the symptoms and hopefully a cure. My son and millions of other patients follow OMF’s work, which they share with their community on a weekly basis. I am part of their translator’s team, who help them reach patients, caregivers and the public in general in many countries around the world.”

Thank you for your support. You give us confidence in our mission to end ME / CFS.

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Check Out Our Redesigned Website 

We are excited to share that we have redesigned and updated our website! Take a look now: www.OMF.ngo

With you in mind, OMF is making website improvements in order to create a user-friendly platform equipped with patient resources, information about OMF’s mission and current research studies, exciting OMF-funded research updates, and more.

What’s new?

We hope you find our website to be a valuable resource, and don’t forget to periodically check back as we continue to make improvements!


If you are able, please consider contributing to our effort to
uncover research-based answers.

Help us improve the quality of life for all sufferers of ME / CFS and other
chronic complex diseases, such as Post Treatment Lyme Disease Syndrome
and Fibromyalgia.


Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

Averting a second pandemic:

Open Medicine Foundation leads groundbreaking international study of

Long COVID’s conversion to ME/CFS

AGOURA HILLS, CALIF.  — Open Medicine Foundation (OMF) is leading a large-scale international collaborative study investigating the potential conversion of Post-Acute Sequelae SARS-CoV-2 infection — more commonly known as Long COVID or Post-COVID Syndrome —  to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic, life-altering disease with no known cause, diagnostic test or FDA approved treatments available.

Up to 2.5 million people in the U.S. alone suffer from ME/CFS; the COVID-19 pandemic could at least double that number. An estimated 35 percent of Americans who had COVID-19 have failed to fully recover several months after infection, prompting many to call it “a potential second pandemic.”

OMF recognized a familiar health crisis emerging, one with eerie similarities to ME/CFS. This crisis presented a unique opportunity to understand how a viral infection — in this case COVID-19 — may develop into ME/CFS in some patients. The goal is to find targeted treatments for ME/CFS patients and ultimately prevent its onset in people infected with SARS-CoV-2 or other infections.

The federal government is only now investing in Post-COVID research, with no focus on its connection to ME/CFS. OMF has already engaged researchers for the largest-scale study of its kind, solely supported by private donors who have contributed over one million dollars to date. When fully funded, the five million dollar, three-year study will be conducted across the globe at OMF funded Collaborative Research Centers, led by some of the world’s top researchers and ME/CFS experts.


In a significant percentage of patients, infections preceded their development of ME/CFS.  For example, according to the CDC about one in ten infected with Epstein-Barr virus, Ross River virus, or Coxiella burnetti develop symptoms that meet the criteria for ME/CFS.


The ability to follow the development of ME/CFS from a known viral infection is unprecedented to date and crucial to researchers’ understanding of the disease. The focus of this study is to find the biological differences between persons returning to good health after COVID-19 and persons who remained ill more than six months after infection and developed ME/CFS.  Understanding these alterations in key pathways can lead to groundbreaking discoveries including new biomarkers, drug targets, and prevention and treatment strategies.


About Open Medicine Foundation

Established in 2012, Open Medicine Foundation leads the largest, concerted worldwide nonprofit effort to diagnose, treat, and prevent ME/CFS and related chronic, complex diseases such as Post Treatment Lyme Disease Syndrome, Fibromyalgia, and Post COVID. OMF adds urgency to the search for answers by driving transformational philanthropy into global research. We have raised over $28 Million from private donors and facilitated and funded the establishment of six prestigious ME/CFS Collaborative Research Centers around the world. To learn more, visit www.omf.ngo.


Heather Ah San

Development and Communications Manager