Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long Covid.

Donate
Sign Up
Main Menu

Cellular Nitrogen and Energy Metabolism in ME/CFS

Study AIM

This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.

LEAD INVESTIGATORS
  • Christopher Armstrong, Phd
  • Paul Gooley, PhD
  • Daniel Missailidis, PhD
  • Jo Cambridge, PhD
  • Neil McGregor, PhD
Updates and Potential
  • Blood-based immune cells from ME/CFS patients appear to die at a faster rate than healthy control cells. Interesting finding but it makes these cells difficult to use for the experiments we are conducting.
  • Lymphoblasts are a more stable and strong cell type that appear appropriate for our metabolism studies.
  • Distinct lipid and amino acid profiles couldbe seen between ME/CFS and controls in lysed lymphoblasts.
  • Data is being collected currently.
STUDY HYPOTHESIS AND DESCRIPTION

ME/CFS is diagnosed by its symptoms, which include post-exertional malaise, fatigue, and brain fog. It is unclear how these symptoms arise, and there are likely multiple routes to arrive at this chronic pathological state. However, there is a fundamental defect in energy metabolism in ME/CFS, which may be a common underlying cause of its symptoms.

We have hypothesized that reactive nitrogen by-products are accumulating in the cells of ME/CFS patients as a result of using amino acids for energy production in the mitochondria.To test this hypothesis, we will culture blood-based immune cells and feed them with labelled sugar, fats and amino acids. As the cells use the labelled sugar, fatand amino acids for energy production we will be able to monitor how their metabolism differs from healthy controls.

OBJECTIVES

  1. Develop method for conducting stable-isotopelabelled cellular metabolism studies.
  2. Observe where Nitrogen atoms flow during energy metabolism in cells from ME/CFS and controls.
  3. Assess the use of carbohydrates, amino acids and ketones by cells from ME/CFS and controls.
Other links you might be interested in:
Latest News
Collaborative Center – Uppsala
Facebook Twitter Youtube Instagram Linkedin
OMF is a non-profit 501(c)(3) organization
(EIN# 26-4712664). All donations are tax-deductible to the full extent allowed by law.

Open Medicine Foundation®
29302 Laro Drive,  Agoura Hills, CA 91301 USA
Phone: 650-242-8669
info@omf.ngo

Contact Us

PRIVACY  |  COOKIE   |   CONSENT   |  MEDICAL & OTHER DISCLAIMERS

Copyright © 2023 Open Medicine Foundation. All Rights Reserved.

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

What are the advantages of giving from your Donor Advised Fund (DAF)?

  • Your gifts to your donor advised fund entitle you to an immediate income tax deduction at the time of contribution.
  • You avoid capital gains tax on appreciated assets you place in your donor advised fund.
  • Your fund’s investment gains accumulate tax free.
  • Funds are distributed to Open Medicine Foundation in your name and immediately put to use to support our worldwide research efforts.

How do I make a donation through my DAF?

Just click on the DAF widget below. It is simple and convenient to find your fund among the over 900 funds in our system.

Still can’t find your fund? 

  • Request a grant distribution through your Donor Advised Fund sponsor
  • Be sure to use OMF’s EIN #26-4712664
  • You can also designate OMF as a beneficiary for your Donor Advised Fund
  • Questions? Give us a call at 650-242-8669 
 

Consent management

Consent Preferences

Data Subject Access Request (DSAR) Form 

Donate