A message to our friends in Sweden.

Open Medicine Foundation (OMF) is very happy to support our Chief Medical Officer Dr. Jonas Bergquist and his cutting-edge work at the ME/CFS Collaborative Research Center (CRC) at Uppsala University, during Triple Giving November.

Donate to “The Uppsala Fund” during Triple Giving November and keep your gift in Sweden! Donations received during Triple Giving November are matched by OMF’s most generous donors, supporting research around the world.

2025 Research and Publications from Uppsala

• • • Large-Scale Biomarker Project—BioQuest 
    • The LIFT
    • Thomas, N., et al. (2025) Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry. J of Transl Med. 23(829). doi:10.1186/s12967-025-06841-4
      • Read a summary of the paper here.
    • Eckey, M., et al. (2025). Patient-reported treatment outcomes in ME/CFS and long COVID. PNAS. 122(28): e2426874122. doi:10.1073/pnas.2426874122
      • Read a summary of the paper here.
    • Fineschi, S., et al. (2025). Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response. Front. Immunol. 16. doi:10.3389/fimmu.2025.1589589
      • Read a summary of the paper here.
    • Kaleta, M., et al. (2025). Targeted analysis of seven selected tryptophan-melatonin metabolites: Simultaneous quantification of plasma analytes using fast and sensitive UHPLC-MS/MS. Journal of Chromatography B, 1256, 124520. doi:10.1016/j.jchromb.2025.124520 (Collaborative Center at Uppsala)
      • Read a summary of the paper here.

About the research center

Established in 2019, this research center is directed by Jonas Bergquist, MD, PhD. Prior to this new center, Dr. Bergquist had already been researching ME/CFS for nearly a decade. Dr. Bergquist and his lab develop novel methods for extracting patient samples and measuring the metabolites and proteins within those samples.

They then apply these methods to produce unique and valuable data from a range of diseases.  Along with ME/CFS, his lab has a general interest in neurodegenerative diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS).

The ME/CFS CRC at Uppsala University is looking for ME/CFS biomarkers to develop a diagnostic test and to contribute to the understanding of what initiates the disease process.  Not only are they looking for single metabolites or proteins, but they are also looking for the pattern of all the data the extract from ME/CFS patient samples and are working towards a defining biochemical signature of the disease.

This collaborative research initiative is looking to develop methods to measure proteins, peptides and metabolites in the blood and cerebrospinal fluid of ME/CFS patients to help define the underlying biological cause, to form a diagnostic and to ultimately find treatments for the disease.

Please support The Uppsala Fund at  Open Medicine Foundation. Donations made through December 2 will be tripled by generous donors and support OMF’s global research initiatives.  And your donation goes directly to the Uppsala CRC!

To learn more about research in Uppsala, visit Uppsala ME/CFS Research Center.