Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM). This includes deep phenotyping of ME patients and global proteomic/metabolomics plasma profiling of ME..
We intend to examine multiple sleep studies that have been conducted in the past two years and performed at the MGH Neurology Sleep Medicine Laboratory in well characterized patients with ME/CFS.
This project will integrate studies in ME/CFS with studies of other well-known diseases to discover the molecular mechanism and identify therapeutic targets of ME/CFS.
Post-exertional malaise is a hallmark of ME/CFS, and the iCPET provides a unique opportunity to investigate the molecular mechanism Sequence Analysis of Viruses and Other Microbes will
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