Extended Big Data Study in Families

Study Aim

Beginning in 2016, the aim of this study was to extend the Severely ill Patient Study (SIPS) and conduct a comprehensive “Big Data” analysis on ME/CFS patients and their families. 

LEAD INVESTIGATORS
  • Fereshteh K. Jahaniani, PhD
  • Michael P. Snyder, PhD
  • Ronald W. Davis, PhD
UPDATES AND POTENTIAL
 

STUDY HYPOTHESIS AND DESCRIPTION

The rationale of this study is that by using the unaffected family members as a control, the differences observed in the ME/CFS patients will be more specific to the disease and less related to differences in genetics, environment, and diet.

STUDY DESIGN

Almost as extensive as the SIPS study, blood from each patient is being used to examine the following:

  • Genome
  • Gene expression
  • Metabolomics
  • Proteomics
  • Cytokines

By comparing patients to healthy blood relatives, we are more likely to understand what genes cause or contribute to the development of ME/CFS. This data will also be integrated with the SIPS data.

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