Neuroendocrine, Vascular and Metabolism in ME/CFS, POTS and Long COVID

We’re exploring the connections between ME/CFS, Long COVID (LC), and POTS, as they often share similar symptoms and frequently occur together, making it challenging for patients to manage their symptoms and maintain a good quality of life.

Recent research suggests that inflammation in the brain might play a role in ME/CFS and LC, with potential pathways involving sustained activation of certain brain cells and inflammation in specific brain areas. This inflammation could affect the balance of a substance called glutamate in the brain, which might contribute to problems with hormone regulation seen in ME/CFS and LC. Additionally, reduced blood flow to the brain could be a common factor in all three conditions.

Our study aims to look at differences in brain structure, blood flow, and biochemistry between these groups to better understand the underlying causes of ME/CFS, LC, and POTS, and to develop treatments that work effectively. By examining various factors like astrocyte activity (a type of brain cell), changes in metabolism, how the brain responds to exercise, and markers of inflammation in the brain, we hope to identify important mechanisms driving symptoms and find potential targets for therapy.