The hypothalamus-pituitary-adrenal (HPA) axis is the communication between three organs: the hypothalamus region of the brain, the pituitary gland, and the adrenal gland. The HPA axis is a major part of the body’s stress management system.
In ME/CFS, the HPA axis has been shown to be dysregulated, meaning the body doesn’t respond to stress signals properly. This dysregulation can be associated with some of the hallmark symptoms of the disease, including fatigue, immune system dysfunction, and sleep disturbances.
OMF’s Melbourne ME/CFS Collaboration is conducting a study on the link between brain blood flow and neuroinflammation, the impact on the HPA axis, and the dysregulation of hormones in ME/CFS, POTS, and Long COVID. Read more about the project and watch interviews with the study team here.
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