Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long Covid

Pesquisa financiada pela OMF: Deformabilidade das hemácias em ME / CFS

Nesta quarta-feira da ciência #OMFScienceWednesday, nós apresentamos um novo projeto que a OMF está financiando e que irá avaliar a deformabilidade das hemácias como um potencial biomarcador para ME / CFS.

As hemácias (glóbulos vermelhos) são as células mais comuns do sangue. O seu papel principal é o transporte de oxigênio e dióxido de carbono no sangue. Este papel depende em parte da deformabilidade / elasticidade ao fluir através dos vasos capilares. Alterações na deformabilidade das hemácias foram associadas a inflamação e a doenças como septicemia, e alguns estudos sugerem que danos nas hemácias ocorrem em ME / CFS. Estas observações, em conjunto com novas tecnologias disponíveis para medir a deformabilidade das hemácias, levaram a equipe do Dr. Ron Davis em Stanford e seus colaboradores na Universidade de San Jose a examinar a deformabilidade das hemácias em ME / CFS.

Em dados preliminares gerados por esta equipe, existem indicações de que a deformabilidade das hemácias é reduzida em alguns pacientes de ME / CFS. As hemácias de pacientes de ME / CFS parecem se mover mais lentamente e se alongar menos do que as de pacientes controle, de acordo com testes utilizando estas novas tecnologias. Nós estamos financiando um projeto para confirmar estes achados em mais pacientes, e para estudar as hemácias utilizando outros métodos, incluindo diversos tipos de microscopia avançada, para melhor entender a razão destas diferenças.

Se estes experimentos tiverem sucesso, eles poderão estabelecer um biomarcador para a ME / CFS que poderia ajudar no diagnóstico e possivelmente na descoberta de novos tratamentos! Fiquem ligados para mais informações.

Aprendam mais sobre hemácias neste vídeo da Khan Academy:

https://www.youtube.com/watch?v=fLKOBQ6cZHA

A OMF agradece a Claudia Musso esta tradução para português.

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

Averting a second pandemic:

Open Medicine Foundation leads groundbreaking international study of

Long COVID’s conversion to ME/CFS

AGOURA HILLS, CALIF.  — Open Medicine Foundation (OMF) is leading a large-scale international collaborative study investigating the potential conversion of Post-Acute Sequelae SARS-CoV-2 infection — more commonly known as Long COVID or Post-COVID Syndrome —  to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic, life-altering disease with no known cause, diagnostic test or FDA approved treatments available.

Up to 2.5 million people in the U.S. alone suffer from ME/CFS; the COVID-19 pandemic could at least double that number. An estimated 35 percent of Americans who had COVID-19 have failed to fully recover several months after infection, prompting many to call it “a potential second pandemic.”

OMF recognized a familiar health crisis emerging, one with eerie similarities to ME/CFS. This crisis presented a unique opportunity to understand how a viral infection — in this case COVID-19 — may develop into ME/CFS in some patients. The goal is to find targeted treatments for ME/CFS patients and ultimately prevent its onset in people infected with SARS-CoV-2 or other infections.

The federal government is only now investing in Post-COVID research, with no focus on its connection to ME/CFS. OMF has already engaged researchers for the largest-scale study of its kind, solely supported by private donors who have contributed over one million dollars to date. When fully funded, the five million dollar, three-year study will be conducted across the globe at OMF funded Collaborative Research Centers, led by some of the world’s top researchers and ME/CFS experts.

BACKGROUND

In a significant percentage of patients, infections preceded their development of ME/CFS.  For example, according to the CDC about one in ten infected with Epstein-Barr virus, Ross River virus, or Coxiella burnetti develop symptoms that meet the criteria for ME/CFS.

THE STUDY

The ability to follow the development of ME/CFS from a known viral infection is unprecedented to date and crucial to researchers’ understanding of the disease. The focus of this study is to find the biological differences between persons returning to good health after COVID-19 and persons who remained ill more than six months after infection and developed ME/CFS.  Understanding these alterations in key pathways can lead to groundbreaking discoveries including new biomarkers, drug targets, and prevention and treatment strategies.

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About Open Medicine Foundation

Established in 2012, Open Medicine Foundation leads the largest, concerted worldwide nonprofit effort to diagnose, treat, and prevent ME/CFS and related chronic, complex diseases such as Post Treatment Lyme Disease Syndrome, Fibromyalgia, and Post COVID. OMF adds urgency to the search for answers by driving transformational philanthropy into global research. We have raised over $28 Million from private donors and facilitated and funded the establishment of six prestigious ME/CFS Collaborative Research Centers around the world. To learn more, visit www.omf.ngo.

CONTACT:

Heather Ah San

Development and Communications Manager

1-650-242-8669

heather@omf.ngo