Open Medicine Foundation®
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ME/CFS and related chronic complex diseases

Symptoms of ME/CFS

ME/CFS is a multi-system disease in which patients experience immune, endocrine, neurological, digestive, and musculoskeletal symptoms. There are over 60 symptoms reported by people with ME/CFS. The common symptoms are listed below but not limited to what may define an individual experience.

Most Common Symptoms

  • Post-exertional malaise (symptoms worsen after exertion)
  • Persistent fatigue
  • Sleep disturbances
  • Pain (muscle pain, headaches)

Neurological | Cognitive Symptoms

  • Brain Fog
  • Confusion and Disorientation
  • Difficulty concentrating
  • Short-term memory issues
  • Ataxia and muscle weakness
  • Hypersensitivity to noise and light

Autonomic | Immune | Digestive Symptoms

  • Orthostatic intolerance
  • Postural Orthostatic Tachycardia Syndrome (POTS)
  • Recurrent flu-like symptoms
  • Sweating / Fever
  • Nausea & IBS
  • New sensitivities to food, medication, chemicals
  • Sore throat
  • Tender lymph nodes
  • Light-headedness
  • Change in body weight
  • Temperature instability
  • Change in appetite

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