Of particular interest are the mitochondria and their role in energy production and resolution of the inflammation that is generated by muscular stress and exercise. It is both possible and even likely that clues for potential biomarkers for PEM will be revealed in these highly detailed studies.
STUDY HYPOTHESIS AND DESCRIPTION
Post Exertional Malaise (PEM) is the key feature of ME/CFS, given the extensive characterization of muscle exertion and recovery in healthy people, the evaluation may indicate how the disease perpetuates.
The hypothesis is that the inflammation-related recovery mechanisms become dysfunctional in the ME/CFS disease, and this dysregulation causes a delayed recovery of muscle after exertional stress.
STUDY DESIGN
Muscle biopsy samples will be taken from ME/CFS patients both at rest and eventually during their recovery from mild to moderate muscular stress. Comparisons will be made to healthy volunteers also at rest, during recovery from muscular stress, and during immobilization.
Using muscle samples, this study will examine the following:
Genomics
Open Medicine Foundation®
29302 Laro Drive, Agoura Hills, CA 91301 USA
Phone: 650-242-8669
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