Copyright © 2023 Open Medicine Foundation. All Rights Reserved.
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
A growing body of literature suggests that energy, amino, and lipid metabolism are clearly implicated in the pathophysiology of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.
Although many studies have shown differences in several metabolites and lipids between ME/CFS and control populations, no single metabolite has been demonstrated to be consistently observed through these studies. This may be due to the high variability amongst ME/CFS patients both clinically and biologically speaking.
One way to overcome this is to conduct repeated measures study designs whereby numerous biological replicates are collected for each patient and control, allowing for each subject to act as their own control. This reduces sources of variation and controls for factors that cause variability between subjects, and is an important technique for research into highly variable or heterogenous populations like ME/CFS.
This study proposes to measure metabolites and lipid species using a novel, sophisticated repeated-measures study design. This will help elucidate the biological mechanisms driving ME/CFS symptoms, and works towards finding clinically useful diagnostic blood tests, and new treatment avenues for ME/CFS patients based on the underlying patho-biology.
What are the advantages of giving from your Donor Advised Fund (DAF)?
How do I make a donation through my DAF?
Just click on the DAF widget below. It is simple and convenient to find your fund among the over 900 funds in our system.
Still can’t find your fund?
Gifting of Stock
DTC #: 0164
Account #: 47083887
Account Registered as:
Open Medicine Foundation
29302 Laro Drive
Agoura Hills, CA 91301
Please speak to your personal tax advisor and then call OMF at 650-242-8669 to notify us of your donation or with any questions.